Ovarian sarcoidosis is probably the second most common manifestation of female genital sarcoidosis.
Since then, there have been other reports of ovarian involvement in sarcoidosis.
In these cases, the diagnosis was based on histopathological findings and other causes of granulomatous inflammation were excluded.
Therefore, it is advisable to carefully examine the pathological samples, because these granulomatous lesions can easily be mistaken for metastases and can cause a dilemma in treatment.
Sarcoidosis is a multi-system disorder that most commonly manifests in the lung system.
Single occurrence of sarcoidosis in the genital area is rare and presents a diagnostic and therapeutic dilemma.
Uterine sarcoidosis can be associated with cervical erosion, polypous endometrial lesions, and recurrent serometers.
In one case, lung sarcoidosis has been associated with vaginal itching and irritation, responding to systemic and topical steroids.
However, this finding is not pathognomic for sarcoidosis, and many infectious and non-infectious etiologies, including some cancers, can cause similar granulomatous reactions in the female genitalia.
The treatment of sarcoidosis is different from the treatment of these other diseases. The most commonly used systemic or local corticosteroids can be dangerous if the underlying cause is infection.
Systemic corticosteroids are the most effective treatment for sarcoidosis. There is limited data on the effectiveness of these agents in skin involvement.
Some lesions, such as plaque and some cases of infiltrating papules or subcutaneous nodules, are associated with chronicity but have little cosmetic significance.
Topical and intravascular therapies with highly effective corticosteroids may be useful in localized diseases.
The treatment of this type of lesions is particularly difficult and is one of the current challenges of sarcoidosis.
Treatment is also indicated when the skin lesions are cosmetically distorted, symptomatic, ulcerative, progressive or prone to scars.
In fact, skin lesions in sarcoidosis primarily require treatment when they are of cosmetic importance to the patient.
The most common specific (granulomatous) skin lesions are spots, subcutaneous nodules, scar sarcoidosis, plaque, and lupus.
Papulo-papular lesions and subcutaneous nodules are associated with remission of systemic disease more often after two years, while plaques, and especially pernio lupus, are features of a chronic disease.
Most skin lesions in sarcoidosis are only mildly symptomatic and do not require treatment.
The first group included patients with papulo-papular and subcutaneous lesions, and the second group included patients with plaques and pernio lupus.
Comparison of the groups showed that the spots and subcutaneous nodules were significantly associated with EN, radiological stage I and remission of systemic disease two years after diagnosis.
In contrast, due to the severity of systemic involvement and persistence of systemic sarcoidosis activity, plaque and lupus pernio were significantly associated with chronic persistent disease and the requirement for corticosteroid treatment for over two years.
Histopathological diagnosis: supraclavicular lymph nodes with chronic, non-tacky, sarcoidosis granulomatous lymphadenitis.
In the early days of hospitalization, the patient had headaches and symptoms of Kernig and Brudzinski.
Computed tomography of the skull showed sufficient differentiation of gray and white matter, normal ventricular system and vascular structures without meninges.
The patient showed clinical improvement in general condition, remission of liver and spleen enlargement, erythema nodosum and loss of lymphadenopathy and testicular weight.
On admission, the patient had type 1 chronic respiratory failure (hypoxemia, normocarbia and hyperlactatemia) without cardiovascular effects.
Chest x-ray showed diffuse reticular and microparticulate infiltrates with bilateral hilar lymphadenopathy according to the American Thoracic Society classification of the second degree according to the thoracic sarcoidosis.
During hospitalization, the patient also had headaches and meningeal symptoms attributable to sarcoidosis infiltration of the meninges, because CSF cytochemical and microbiological analyzes were normal and skull computed tomography.
Krajicek et al. (2009) reported that Langerhans pulmonary histiocytosis (plch) is an inflammatory lung disease that is strongly associated with cigarette smoking and an increased risk of cancer.
Patients with nodular disease that have been observed during computed tomography of the breast are more likely to have an abnormal PET scan.
They indicated that these results suggest that PET scan imaging cannot reliably distinguish benign inflammatory PLCH nodal lesions from malignant lesions.
It can damage important body organs with symptoms that plateau or deteriorate, or remorse, as with other autoimmune diseases.
Some people may have mild symptoms of dry eyes and lips, while others may have symptoms of serious illness.
Others suffer from blurred vision, persistent eye discomfort, recurrent oral infections, swollen parotid glands, dysphonia (voice disorders, including hoarseness), and difficulty swallowing and eating.
Some patients may experience kidney involvement (autoimmune tubulo-interstitial nephritis), which leads to proteinuria (excess protein in the urine), defects of urine deficiency and distal tubular acidosis.
The break itself can be caused by injury, bite of an animal or insect or a prick after several operations with some medications or skin wounds due to conditions such as diabetes or peripheral vascular disease.
Untreated bacterial infection can lead to tissue death (gangrene), sepsis, generalized infection, shock, meningitis (cellulitis) and lymphangitis (lymphangitis).
For example, a fungal infection is Candida skin, which occurs in warm, moist body crevices, a common cause of diaper dermatitis and vaginal yeast infection.
Diseases such as endometriosis and pelvic inflammatory disease can lead to painful sex.
Scars from pelvic surgery and some cancer treatments can also cause painful sex.